Maribavir is a benzimidazole riboside with activity against cytomegalovirus (CMV). The safety and efficacy of maribavir for preemptive treatment of CMV infection in transplant recipients is not known. Design adds clarity. Using colour, typo graphy, hierarchy, contrast, and all the other tools at their disposal, designers can take an unordered jumble of… In a phase …
Here’s some worrisome news for folks who manage to survive a heart attack: New research suggests they might be far more vulnerable to developing cancer down the road. People who suffered a heart health scare — a heart attack, heart failure or a dangerously erratic heart rhythm — had a more than sevenfold increased risk …
Millions of Americans take an ACE inhibitor to help curb their high blood pressure — in fact, these drugs are the most widely used antihypertensives in America. However, a new international study of nearly 5 million patients is casting doubt on the notion that the drugs are as effective as another class of blood pressure …
MONDAY, Dec. 2, 2019 (HealthDay News) — Brushing your teeth may be good for your heart, a new study suggests.It included more than 161,000 South Korean adults, ages 40 to 79, with no history of heart failure or the heart rhythm disorder atrial fibrillation. Between 2003 and 2004, participants had a routine medical exam and …
Chronic hepatitis B (CHB) remains a major global healthcare challenge with changing epidemiology and increasing morbidity and mortality from the complications of liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B virus infection can be broadly categorized into four disease phases: (1) hepatitis B e antigen (HBeAg)-positive chronic infection; (2) HBeAg-positive chronic hepatitis; (3) HBeAg-negative chronic …
Objective: To estimate the prevalence of polypharmacy among Australians aged 70 years or more, 2006–2017. Design, setting and participants: Analysis of a random 10% sample of Pharmaceutical Benefits Scheme (PBS) data for people aged 70 or more who were dispensed PBS‐listed medicines between 1 January 2006 and 31 December 2017. Main outcome measures: Prevalence of continuous polypharmacy (five …
Immunosenescence involves a series of ageing-induced alterations in the immune system and is characterized by two opposing hallmarks: defective immune responses and increased systemic inflammation. The immune system is modulated by intrinsic and extrinsic factors and undergoes profound changes in response to the ageing process. Immune responses are therefore highly age-dependent. Emerging data show that …
T cell activation and function require a structured engagement of antigen-presenting cells. These cell contacts are characterized by two distinct dynamics in vivo: transient contacts resulting from promigratory junctions called immunological kinapses or prolonged contacts from stable junctions called immunological synapses. Kinapses operate in the steady state to allow referencing to self-peptide-MHC (pMHC) and searching …
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