Hospital admissions because of alcohol-related liver disease (ArLD) are increasing. The amount of alcohol consumed and pattern of drinking are linked to increased risk of ArLD. However, other factors such as obesity, co-existent liver disease – particularly hepatitis C, gender, nutritional status and genetic factors also play a role. The spectrum of ArLD ranges from …
Optimal protein synthesis requires bases in transfer RNAs to be modified. A key modification has been shown to involve an unusual two-step mechanism that entails the sequential activities of two enzymes. A central dogma of molecular biology is that DNA and the corresponding RNA are complementary. But this complementarity is rewired by a process called …
Jaundice, also known as icterus, is a yellowing of the skin, whites of the eyes, and body fluids due to an increase in the amount of bilirubin in the blood. Bilirubin is a yellowish pigment and byproduct of the natural daily breakdown of red blood cells (RBCs). Red blood cells typically survive for about 120 …
Patients with liver disease often require drug therapy. Because the liver is the main site of drug detoxification and elimination, each patient’s need for therapy must be carefully assessed; the choice of drug, its dose and the duration of therapy must be carefully considered to avoid adverse effects. Ideally, one should choose a drug that …
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